3吩嗪-1-羧酸水悬浮剂的制备研究

摘要

Screening and optimization for the adjuvant system of phenazine-1- carboxylic acid (PCA) 3% suspension formulation have been performed. The PCA 3%suspension was prepared by wet grinding and indicators were measured. The formula was PCA 3%, A11 3%, M16 2%, OP-10 4%, xanthan gum 0.7%, magnesium aluminum silicate 0.5%, glycerol 5%, simethicone 1%, sodium benzoate 1%, distilled water adds to 100%. Samples prepared using the formula have stable performance and each indicators of the preparation is in line with the relevant standards for suspension.%通过对3%吩嗪-1-羧酸水悬浮剂助剂的筛选和优化，确定最佳配方。试验采用湿式研磨法制备3%吩嗪-1-羧酸水悬浮剂，对各个指标进行测定。正交优化最佳配方：PCA 3%、分散剂A113%，润湿剂M162%，乳化剂OP-104%，增稠剂黄原胶0.7%、硅酸镁铝0.5%，防冻剂丙三醇5%，消泡剂甲基硅油1%，防腐剂苯甲酸钠1%，去离子水补足100%。用该配方制备的悬浮剂样品，性能稳定，各个性能指标均优于相关标准。