Background/Aims: To determine the prevalence and risk factors of fatty liver (FL) among Shanghai adults. Methods: A cross-sectional ultrasonographic survey with randomized multistage stratified cluster sampling was used. Results: The study included 3175 subjects (1218 men)with amean age of 52 years. FL was found in 661 (20.82% ) subjects. After adjustment by age and sex, FL prevalence was found to be 17.29% , and the prevalences of alcoholic, suspected alcoholic and nonalcoholic FL were determined to be 0.79, 1.15 and 15.35% , respectively. Generally, age, body mass index (BMI), waist circumference, blood pressure, and the prevalences of obesity, diabetes, hypertension and dyslipidemia were all significantly higher in FL patients than in controls; In contrast, the levels of high-density-lipoprotein cholesterol (HDL-C), education and physical activity were markedly lower. Multiple regression analyses showed that only nine factors (male, educational level, waist circumference, BMI, HDL-C, triglyceride, fasting plasma glucose, diabetes and hypertension) were closely related to FL. In excessive drinkers, obesity increased the risk for FL by 4.8-fold, but excessive drinking was associated with only a 1.5-fold increased risk in obese subjects. Conclusions: FL in Shanghai is highly prevalent and mainly related to multiple metabolic disorders.
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