Purpose: This review emphasizes the importance of neuro-oph-thalmological si gns and symptoms in sarcoidosis. The presence of ophthalmological and neuro-oph thalmolo- gical findings may lead to diagnosis of the disease and the initiation of adeq uate treatment. Material and Methods: Patients who had been diagnosed with neuro sarcoidosis during the period 1990-2001 were identified from the departmental d iagnostic index. The history, clinical, laboratory and imaging data of patients were analysed. Results: Fifteen patients were identified, four men and 11 women, with a mean age of 44.1 years (range 26-65 years). In six of the 15 (40%), ne urological deficits were the initial symptoms. Nine (60%) had known sarcoidosis at the time of presentation. Ten patients (66%) had ophthalmologi-cal/neuro- ophthalmological symptoms and signs. Conclusion: Neuro-ophthalmological symptom s may develop early in neurosarcoidosis. If neuro-ophthalmolog- ical symptoms arise in patients with established biopsy-proven sarcoidosis, t he diagnosis is usually easy to make. However, a number of patients with neurosa rcoidosis may present with neuro-ophthalmic symptoms before systemic involvemen t becomes obvious. In this situation the diagnosis is challenging, and the major goal is to establish the presence of systemic sarcoidosis.
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