cqvip:Tazarotene and calcipotriol are both effective in the treatment of psoriasis. An investigator- blind, bilateral comparison of 44 lesion pairs in 19 patients was conducted to evaluate the efficacy, side effects and duration of therapeutic effects of once- daily tazarotene 0.1% gel plus petrolatum with twice- daily calcipotriol 0.005% ointment in plaque psoriasis. It consisted of a 12- week treatment phase, followed by a 4- week post- treatment observation phase. At the end of the treatment phase, tazarotene- petrolatum was as effective as calcipotriol in both objective and subjective overall efficacy assessment. Calcipotriol had a significantly greater effect in reducing erythema than tazarotene- petrol- atum at weeks 2- 8. At week 16, tazarotene- petrolatum demonstrated a significantly better maintenance effect in all parameters. Local irritation was noted only intazarotene- petrolatum- treatedlesions. Once- dailytazarotene 0.1% gel plus petrolatum was as effective as twice- daily calcipotriol 0.005% ointment in the treatment of plaque psoriasis,but had a better maintenance effect after the cessation of therapy.
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