Objective To observe the effect of 0.1% cream tazarotene combined with 0.005% ointment calcipotriol in the treatment of seborrheic keratosis (SK).Methods157 patients with SK were randomly divided into four groups:placebo group topically applying 1% cream vitamin E, 3 times/d, treatment group 1 topically applying 0.1% cream tazarotene, 1 times/d, treatment group 2 topically applying 0.005% ointment calcipotriol, 2 times/d, treatment group 3 topically applying 0.005% ointment calcipotriol, 2 times/d, 0.1% cream tazarotene, 1 times/d. To observe the subsidence of lesions and pigmentation, the adverse reaction in 2,4 weeks.Results The effective rate of the placebo group, the treatment group 1,2,3 was respectively 18.2%,64.4%,64.4%, 91.1%. Comparison with placebo group, the effective rate of treatment group 1,2 was higher signiifcantly (χ2=18.14,P=0.000;χ2=15.52,P=0.000).The effective rate of the treatment group 1,2 both were 64.4%(χ2=0.65,P=0.94);The effective rate of treatment group3 was 91.1%, it was signiifcantly higher than group1 or group2 (χ2=10.78,P=0.011;χ2=12.11, P=0.011).Conclusion The effect of 0.1% cream tazarotene combined with 0.005% ointment calcipotriol in the treatment with SK was satisfactory, especially for the elderly patients.%目的：观察0.1%他扎罗汀乳膏联合0.005%卡泊三醇软膏治疗脂溢性角化病（Seborrheic Keratosis，SK）的疗效。方法：157例SK患者，随机分组为：安慰组：22例，外用1%维生素E乳膏，每日3次；治疗1组：45例，外用0.01%他扎罗汀乳膏，每晚1次；治疗2组：45例，0.005%卡泊三醇软膏，每日2次；治疗3组：45例，0.005%卡泊三醇软膏，每日2次，同时外用0.1%他扎罗汀乳膏，每晚1次。2、4周后复诊，观察皮损消退情况、色素减退情况及不良反应。结果：安慰组、治疗1组、治疗2组与治疗3组有效率分别为18.2%、64.4%、64.4%、91.1%。治疗1组、治疗2组与安慰组比较，差异有统计学意义（χ2=18.14，P=0.000；χ2=15.52，P=0.000）；治疗1组、治疗2组有效率均为64.4%，差异无统计学意义（χ2=0.65， P=0.94）。治疗3组有效率为91.1%，与治疗1组、治疗2组比较，差异有统计学意义（χ2=10.78，P=0.011；χ2=12.11， P=0.011）。结论：联合0.1%他扎罗汀乳膏与0.005%卡泊三醇软膏治疗SK疗效满意，治疗老年SK患者方便，优于其他方法。
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