cqvip:Objective: To smtudy the association between white matter lesions (WML) in spe cific locations and the risk of dementia. Design: The Rotterdam Scan Study, a pr ospective population based cohort study. We scored periventricular and subcortic al WML on magnetic resonance imaging and observed participants until January 200 2 for incident dementia. Setting: General population. Participants: We included 1077 people aged 60 to 90 years who did not have dementia at baseline. Main Outc ome Measure: Incident dementia by Diagnostic and Statistical Manual of Mental Di sorders, Third Edition (DSM III R) criteria. Results: During a mean follow up of 5.2 years, 45 participants developed dementia. Higher severity of periventric ular WML increased the risk of dementia, whereas the association between subcort ical WML and dementia was less prominent. The adjusted hazard ratio of dementia for each standard deviation increase in periventricular WML severity was 1.67 (9 5%confidence interval, 1.25-2.24). This increased risk was independent of othe r risk factors for dementia and partly independent of other structural brain cha nges on magnetic resonance imaging. Conclusion: White matter lesions, especially in the periventricular region, increase the risk of dementia in elderly people.
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