To evaluate prognostic factors that impacts the survival of women with sex cor d stromal tumors of the ovary (SCST). Cases were identified from tumor registry databases at three academic institutions between 1975 and 2003. Patient characte ristics, surgical treatment, adjuvant therapy, pathologic and follow-up informa tion were collected from hospital charts and clinic records. Kaplan-Meier and C ox proportional hazards analyses were used to identify predictors of outcome. Ei ghtythree women (median age: 49 years) with SCST of the ovary, including 73 with granulosa and 10 with Sertoli-Leydig cell tumors were identified. Fifty-one w ere stage I, 8 stage II, 10 stage III, 3 stage IV, and 11 patients were unstaged . The median and 5-year disease-specific survival of women with stage I-II vs . III-IV was 180 months and 85%compared to 58 months and 48%, respectively (P = 0.012). Furthermore, age < 50 (P = 0.003), premenopausal status (P = 0.013), tumor size < 10 cm (P = 0.003), lack of lymph node invasion (P < .0.0005), and a bsence of residual disease (P = 0.002) were all significant predictors for improved surv ival. Of the patients who received adjuvant treatment, chemotherapy did not impa ct survival (P = 0.11). Twelve of 51 stage I patients underwent fertility-spari ng surgery with three recurrences. In multivariate analysis, age <50, smaller tu mor size, and absence of residual disease remained as independent prognostic fac tors. The median follow up was 58 months (range: 1-310). Age < 50, smaller tumo r size, and absence of residual disease are important predictors for improved su rvival in patients with SCST of the ovary.
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