Objective to investigate the relationship between the average platelet volume distribution and severity of coronary atherosclerosis in a multi-ethnic population. Methods seven hundred and twenty-one adult subjects (448 subjects were of Han nationality, 125 subjects were from Uygur, 63 subjects were from Kazakh, 51 subjects were from Hui, and 35 subjects were of other nationalities.) who underwent coronary angiography for suspected or known coronary atherosclerosis were enrolled in the present study. the average platelet volume of the subjects’ was measured by the automate blood analyzer, and, the severity of coronary atherosclerosis was defined by the Gensini score. Results a significant difference regard as the level of average platelet volume was found among the various ethnic groups (p=0.000). spearman correlation analyses indicated that the Gensini score was signifi-cantly associated with average platelet volume (r=-0.130, p=0.001). Multiple regression analyses suggested that the level of average platelet volume (β=-0.124,p=0.004) was independently associated with the Gensini score. Conclusion the level of average platelet volume was significantly associated with the severity of coronary ath-erosclerosis in the multi-ethnic population.% 目的探讨多民族间平均血小板体积分布与冠状动脉粥样硬化严重程度的关系.方法本课题组入选721例拟诊为冠心病并行冠脉造影术的多民族患者,其中汉族448例；回族51例；维吾尔族125例；哈萨克族63例；其他民族35例.应用全自动血液分析仪检测平均血小板体积分布,采用Gensini评分系统对冠状动脉血管病变程度进行定量评分获得Gensini积分,单因素及多因素统计分析平均血小板体积分布与冠状动脉粥样硬化严重程度的关系.结果平均血小板体积分布在不同民族间(p=0.000)分布具有统计学差异.spearman 相关分析结果显示在双变量的spearsan相关性分析中,平均血小板体积(r=-0.130,p=0.001)与Gensini积分呈负相关.多元线性回归分析结果显示,在多民族中,平均血小板体积(β=-0.124,p=0.002)与Gensini积分独立相关.结论多民族中,平均血小板体积分布与冠状动脉粥样硬化严重程度呈负相关,对冠状动脉粥样硬化严重程度具有预测意义.
展开▼
