Objective to provide a theoretical basis for the patients with moderate and severe esophageal mucosal atypical hyperplasia to make local excision early through the detection of foxp3 expression in patients with esophageal mucosal atypical hyperplasia and squamous cell carcinoma of esophagus. Methods the samples of 35 cases treated with esophageal squamous cell carcinoma resection and 42 cases with esophageal mucosa atypical hyperplasia treated with biopsy and 10 cases with normal esophageal mucosa were selected from 2008 to 2009, and immunohistochemistry was used to detect the expression of foxp3 in normal esophageal mucosa, atypical hyperplasia tissue and esophageal squamous carcinoma. Results the expression of foxp3 in esophageal mucosa dysplasia (χ2=4.289, P<0.05) and esophageal cancer tissues (χ2=6.710, P<0.05) were significantly higher than that in normal mucosa. The expression of Foxp3 showed statistical significance between mild atypical hyperplasia and moderate and severe atypical hyperplasia tissue and esophageal squamous cell carcinoma (χ2=7.274, P<0.05). it showed higher expression of Foxp3 in esophageal carcinoma and severe atypical hyperplasia, but the difference was not statistically significant (χ2=0.000, P>0.05). Conclusion the over expression of foxp3 in esophageal dysplasia esophageal carcinogenesis, suggested the turning point in the progress of the disease. therefore, foxp3 may act as a molecular sign for local excision of lesion.%目的：通过检测 foxp3在食管粘膜不典型增生及食管鳞癌患者中的表达，为食管粘膜中重度不典型增生患者早期行局部切除提供理论依据。方法收集我院2008年至2009年手术切除的食管鳞癌标本35例及食管粘膜不典型增生胃镜活检标本42例，健康志愿者正常食管粘膜10例；免疫组化方法检测 foxp3在食管正常黏膜、不典型增生组织、食管鳞癌组织的表达。结果 foxp3在食管粘膜不典型增生（χ2=4.289，P <0.05）及食管癌组织中（χ2=6.710，P <0.05）的表达均显著高于正常粘膜组织。foxp3在轻度不典型增生、中重度不典型增生组织及食管鳞癌组织中的表达差异有统计学意义（χ2=7.274，P <0.05）。foxp3在食管癌组织中的表达高于中重度不典型增生组织，但差异无统计学意义（χ2=0.000，P >0.05）。结论 foxp3在食管重度不典型增生中过度表达，提示食管黏膜癌变进入疾病进展的转折点， foxp3可能作为病变需要局部切除的分子标志。
展开▼
