目的：观察重组人生长激素（rhGH）对早产儿生长发育的影响。方法：选取31周32周33周34周体重小于1500克大于1000g的早产儿各20名，随机分为实验组和对照组。实验组给予重组人生长激素0.1U/KG/日临睡前皮下注射，并给予静脉营养治疗，对照组给予静脉营养治疗。比较体重、头围、皮质醇、前白蛋白、血红蛋白、肿瘤坏死因子变化。结果：应用重组人生长激素后,体重、头围、前白蛋白、肿瘤坏死因子实验组与对照组存在显著差异（P<0,05），组间有显著性差异（P>0.05）；对照组血红蛋白、皮质醇实验组与对照组无统计学差异（P>0.05），组间有统计学差异。结论：rhGH结合静脉营养治疗有助于早产儿骨骼、肌肉生长发育，有统计学差异，对血液系统、免疫系统生长发育有作用，但无统计学差异。%Objective:To observe the influence of the recombinant human somatropin on the growth and development of the infants with very low birth weight. Methods: The infants who were 31, 32, 33, and 34 weeks old were chosen with the weight ranging from 1000g to 1500g. 20 infants were selected for each age. They were randomly divided into an experimental group and a control group. The experimental group was treated with the subcutaneous injection of recombinant human somatropin, 0.1U/KG a day before sleeping, as well as the parenteral nutrition therapy. But the control group was only treated with the parenteral nu-trition therapy. Then the author compared the changes of weight, head circumference, cortisol, albumin, hemoglobin, tumor necrosis factor of the infants. Results:The experimental group and the control group were significantly different in the aspects of the weight, head circumference, prealbumin and tumor necrosis factor of the infants (P<0,05) . No significant difference was examined in the hemoglobin and cortisol of the two groups (P>0.05) . Results: The rhGH combined with the parenteral nutri-tion therapy is helpful for the growth and development of the bones and muscles and it has statistical significance. Besides, it can help the growth and the development of the blood system and the immune system of the infants, although it has no statistical significance.
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