睡眠医学及血压变异性对合理应用降压药的临床重要性

摘要

Compared with office blood pressure measurements,ambulatory blood pressure monitor has the advantage of revealing the general blood pressure level and better indicating target organ damage.Blood pressure is closely related to biological circadian rhythm,and commonly classified as dipping,extreme dipping,non -dipping,and reverse dipping types.The study of BP variation is inseparable to sleep medicine and BP variation should be involved in appropriate medication strategies,which is a key part to chronopharmacology,and a significant application of interdisciplinary medicine.%动态血压监测与偶测血压相比，能更全面更准确地反映血压的整体水平，并且能够更好地预测靶器官的损害。血压与人体的生物节律密切相关，其昼夜波动通常分为杓型、深杓型、非杓型、反杓型这四种类型的节律。血压变异性的研究与睡眠医学密不可分。针对血压的节律性变异，临床上指导患者适时适量地服用降压药是非常必要的。这既是时辰药理学关注的内容，也是睡眠医学在多学科交叉的临床实践意义之一。