Epidemiological and clinical features of hepatitis B virus related liver failure in China

摘要

AIM:To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China.METHODS:This study was conducted with a retrospective design to examine 1066 patients with HBVrelated liver failure in the southwest of China.RESULTS:There were more male than female patients.Young and middle-aged people comprised most of the patients.Farmers and laborers comprised the largest proportion (63.09%).Han Chinese accounted for 98.12%,while minority ethnic groups only accounted for 0.88% of patients.A total of 43.47% patients had a family history of HBV-related liver failure and 56.66% patients had a history of drinking alcohol.A total of 42.59% patients with HBV-related liver failure had definite causes.With regard to the clinical manifestation of HBV-related liver failure,the symptoms were:hypodynamia,anorexia and abdominal distension.Total bilirubin (TBIL) and alanine aminotransferase (ALT) levels were altered in 46.23% of patients with evident damage of the liver.Univariate logistic regression analysis showed that the patients' prognoses were correlated with ALT,aspartate aminotransferase,albumin,TBIL,prothrombin activity (PTA),and alpha-fetoprotein levels,and drinking alcohol,ascites,hepatorenal syndrome,infection and ≥ 2 complications.Multifactor logistic regression analysis showed that the activity of thrombinogen and the number of complications were related to the prognosis.CONCLUSION:Alcohol influences the patients' prognosis and condition.PTA and complications are independent factors that can be used for estimating the prognosis of HBV-related liver failure.