Systematic review of the non surgical management of Peyronie''''s disease

摘要

This systematic review shows the“Status quo”on medical treatment for Peyronie’s disease(PD).PD is a connective tissue disorder,characterised by the formation of a fibrotic lesion or plaque in the tunica albuginea,which leads to penile deformity.The aetiology of PD is unknown.Nowadays the most widely accepted hypothesis proposed by Gonzalez-Cadavid et al,is repetitive microvascular injury or trauma to the tunica albuginea.Physicians have proposed several medical alternatives for treatment of this disease with few effective results.Nevertheless,as of today nonsurgical options are currently available,and some of them are able to stabilize or even reduce deformity while improving pain relief and sexual function.A systematic literature search throughout the Medline database was carried out.The controlled vocabulary of the medical subject headings database employs the specific term“penile induratio”for PD.A total of 50 articles on PD were found.Studies were selected based on clinical relevance.The recommended standard of care for PD involves an initial treatment in the acute phase.Several non-operative treatment options have been used.Unfortunately no further substantial,quality evidence on the use of medical therapy currently exits.There is,however,an increasingly enhanced interest in this disorder and basic scientific and clinical research will eventually lead to a more effective methodology to study the disease.