Association between functional abdominal pain disorders and asthma in adolescents:A cross-sectional study

摘要

AIM To find the association between asthma and different types of functional abdominal pain disorders(FAPDs)among teenagers.METHOD A cross-sectional study was conducted among 13 to 15-year-old children from six randomly selected schools in Anuradhapura district of Sri Lanka.Data were collected using translated and validated selfadministered questionnaires(RomeⅢquestionnaire,International Study on Asthma and Allergies in ChildSubmithood questionnaire,and Pediatric Quality of Life Inventory 4.0)and administered under an examination setting after obtaining parental consent and assent.RESULTS Of the 1101 children included in the analysis,157(14.3%)had asthma and 101(9.2%)had at least one FAPDs.Of children with asthma,19.1%had at least one type of FAPDs.Prevalence rates of functional abdominal pain(FAP)(8.9%vs 3.3%in nonasthmatics),functional dyspepsia(FD)(2.5%vs 0.7%),and abdominal migraine(AM)(3.2%vs 0.4%)were higher in those with asthma(P<0.05,multiple logistic regression analysis),but not in those with irritable bowel syndrome(4.5%vs 3.1%,P=0.2).Severe abdominal pain(10.8%vs 4.6%),bloating(16.6%vs 9.6%),nausea(6.4%vs 2.9%),and anorexia(24.2%vs 16.2%)were more prevalent among asthmatics(P<0.05).Lower gastrointestinal symptoms did not show a significant difference.Scores obtained for health related quality of life(HRQoL)were lower in those with asthma and FAPDs(P<0.05,unpaired t-test).CONCLUSION Asthma is associated with three different types of FAPDs,namely,FD,AM,and FAP.HRQoL is significantly impaired in teenagers with asthma and FAPDs.