Objective:To test the hypothesis that oxidative stress signaling contributes to post-transplant endothelial dysfunction and hypertension in pediatric post-transplant hypertension. Study design:This study evaluated in 16 pediatric renal transplant patients,divided in two groups based on the presence of post transplant hypertension,the oxidative stress status measuring the gene expression (reverse transcription-polymerase chain reaction)of two major oxidative stress-related proteins,p22phox and heme oxygenase-1(HO-1). Total plasma antioxidant power(ELISA)was also evaluated. Results:Mononuclear cell p22phoxgene expression was higher in hypertensive patients compared with the normotensive group (0.91 ±0.06 vs 0.79 ±0.08 densitometric units,P < 0.02),whereas HO-1 RNA production and total plasma antioxidant power were higher in the normotensive group (0.38 ±0.04 vs 0.20 ±0.11 d.u.,P < 0.006,and 1189.35±145.75 vs 772.71 ±196.03 μmol/L,P < 0.01,respectively).Conclusions:Oxidative stress is associated with post-transplant hypertension in hypertensive pediatric kidney-transplant patients,who therefore are at risk of oxidative stress-induced organ damage. They might benefit from treatments addressing not only hypertension but also oxidant-related complications.
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