川椒方治疗小鼠变应性结膜炎的实验研究

摘要

目的:验证川椒方对变应性结膜炎的治疗作用,并初步探讨其作用机制.方法:通过实验观察不同浓度川椒方对小鼠变应性结膜炎模型的临床体征及结膜病理切片改善作用评价其疗效,并通过其对血清IgG1、IgE、IL-4的改变初步探讨其作用机理.结果:川椒方能明显改善模型小鼠眼部急性体征、减少晚期细胞反应,降低血清IgG1、IgE、IL -4的水平.结论:川椒方对小鼠的变应性结膜炎有明显的治疗作用,其作用机理与能有效降低相关血清免疫球蛋白及免疫因子水平有关.%Objective:To confirm efficacy of Pricklyash Peel Decoction on allergic conjunctivitis, and to make a preliminary analysis on its action mechanism. Methods:To observe improvement of vital signs and changes of pathological section by various concentrations of the decoction. Blood serum was taken to determine changes of parameters including IgGl, igE and IL-4. Results;Pricklyash Peel Decoction has significantly improved the model rats'eye acute symptoms, decreased reaction of late cell and reduced the levels of IgGl, IgE and IL-4 in blood serum. Conclusions : Pricklyash Peel Decoction has active effect on allergic conjunctivitis. Its action mechanism is related to effective decrease of immune globulin and immune factors in blood serum.