基于数据挖掘的国医大师颜正华含赤芍处方用药规律研究

摘要

Objective:To explore the medication rules of State medical master Yan Zhenghua.Methods:The prescriptions including Ra-dix Paeoniae Rubra that built by Pro.Yan were collected to build a database based on Traditional Chinese Medicine (TCM)inheritance assist system.After analyzing the statistical reports module and the data analysis module which were from TCMinheritance assist system, the methods of data-mining including association rules and apriori algorithm were used to analyze the frequency of single medicine,the frequency of drug combination,the association rules between drugs and core drug combinations of prescriptions that all included Radix Paeoniae Rubra.Results:The prescriptions including Radix Paeoniae Rubra were commonly used to treat megrim,stomach-ache,arthral-gia-synadrome and other syndromes.The highest frequency used drugs were Cortex Moutan,Radix Paeoniae Alba,Pericarpium Citri Retic-ulatae.The most frequency drug combinations were “Radix Salviae Miltiorrhizae,Radix Paeoniae Rubra”,“Radix Paeoniae Alba,Radix Paeoniae Rubra”,“Radix Paeoniae Rubra,Pericarpium Citri Reticulatae”.The drug association rules whose confidence level was 1 were“Radix Glycyrrhizae->Radix Paeoniae Rubra”,“Cortex Moutan->Radix Paeoniae Rubra”,“Chaff Flower Root->Radix Paeoniae Rubra”,and “Radix Paeoniae Alba->Radix Paeoniae Rubra”.Conclusion:The drugs in the prescriptions containing Radix Paeoniae Rubra that built by Pro.Yan mostly have the effects of regulating the flow of qi and invigorate blood circulation,which reflects the clearly thoughts when making prescriptions.%目的：探讨国医大师颜正华教授处方用药规律。方法：在收集处方的基础上，基于中医传承辅助系统构建数据库，使用软件的统计报表模块、数据分析模块，关联规则 apriori 算法等数据挖掘方法，分析含赤芍处方中单味药物频次、药物组合频次、关联规则与核心药物组合等。结果：含赤芍处方常用于治疗眩晕、胃痛、痹证等病证，高频次药物包括牡丹皮、白芍、陈皮等；高频次药物组合包括“丹参，赤芍”“白芍，赤芍”“赤芍，陈皮”等，置信度为1的关联规则包括“甘草－＞赤芍”“牡丹皮－＞赤芍”“牛膝－＞赤芍”“白芍－＞赤芍”等。结论：颜正华教授含赤芍处方所用药物多具有理气活血之功效，用药集中，组方法度清晰。