健脾调肝汤治疗晚期原发性肝癌对生活质量的影响

摘要

Objective:To observe impact of Jianpi Tiaogan Tang on the life quality of patients with terminal primary liver cancer.Meth-ods:Sixty patients were randomized to receive western medicine treatment ( protecting liver, lipid lowering, pain relief, etc.) , the treat-ment group took Jianpi Tiaogan Tang on top of western medicine treatment.After 2 treatment courses (1 month/course) , efficacy were evaluated.TCM syndrome, life quality, weight changes, liver function changes and adverse reaction were observed.Results:In terms of TCM syndrome changes, the total improvement rate of treatment group and control group were 83.3%and 60.0%respectively (P<0. 05);after treatment, the treatment group was significantly better than control group in terms of life quality, weight stabilization (P<0. 05);in terms of liver function, after treatment both groups showed significantly improved ALT、AST、TBil (P<0.05).Treatment group had even better ALT, ASL levels compared to control group (P<0.05).No adverse reaction was observed in both groups.Conclusion:Jianpi Tiaogan Tang can alleviate clinical symptoms of terminal primary liver cancer, reducing liver damage and adverse reaction, im-prove quality of life and prolong lifetime.%目的：观察健脾调肝汤治疗晚期原发性肝癌对生活质量的影响。方法：将60例患者随机分成治疗组与对照组各30例，2组患者均采用相同的西药（保肝、降酯、止痛等）治疗；治疗组同时加用健脾调肝汤治疗。2组均治疗1个月为1个疗程，2个疗程后评价疗效。观察2组中医证候变化、生活质量、体重变化、肝功能变化及不良反应。结果：2组中医临床证候变化比较，治疗组与对照组总改善率分别83．3％与60．0％（P＜0．05）；2组治疗后生活质量及体重变化比较，生活质量、体重治疗组高于对照组（P＜0．05）；2组治疗后肝功能变化比较，2组治疗后肝功能3项指标（ALT、AST、TBIL）较治疗前均有明显改善（P＜0．05），其中ALT、AST水平治疗组较对照组改善更明显（P＜0．05）。不良反应2组未见明显发生。结论：健脾调肝汤治疗晚期原发性肝癌可改善临床症状，减轻肝损害及不良反应，提高生活质量、延长生存期。