抗氧化作用样中药单体抑制 Ox-LDL 生成保护血管内皮细胞作用的研究进展

摘要

氧化低密度脂蛋白（Oxidized Low Density Lipoprotein，Ox-LDL）的形成对动脉粥样硬化（Atherosclerosis，AS）的发生发展起到很关键的作用，主要通过刺激相关受体、分泌细胞因子等诱导内皮细胞损伤，加重 AS。近年来国内外对中药单体抗低密度脂蛋白氧化，减少对血管内皮细胞损伤，起到预防治疗动脉粥样硬化，保护心血管作用有很多报道。本文就近年来的中药单体抗 Ox-LDL，保护心血管疾病的相关研究进行综述。%Oxidized low-density lipoprotein (Ox-LDL)plays an important role in the formation of atherosclerosis (AS).It induces endothelial cell injury and aggravates AS by stimulating the relevant receptors,secreting cytokine and so on.In recent years,there are more and more reports about the antioxidant effect of Chinese medicine monomer in preventing and treating AS by reducing en-dothelial cell injury.This paper gives a summary review of some researches on the relationship between Ox-LDL and cardiovascular disease in recent years.