脾阴虚血瘀治疗方案在糖尿病性胃轻瘫患者中的应用价值探究

摘要

目的：探究脾阴虚血瘀治疗方案在糖尿病性胃轻瘫患者中的综合应用价值。方法：将2014年1月至2015年12月于本院进行诊治且符合中医脾阴虚血瘀证的120例糖尿病性胃轻瘫患者按照随机数字表法分为2组，对照组的60例患者进行常规西医治疗，治疗组的60例患者则以脾阴虚血瘀治疗方案进行治疗，然后将2组治疗后1周、2周和4周的总有效率、治疗前和治疗后1周、2周和4周的症状积分、餐前及餐后胃电参数指标、疾病相关血清指标及生活质量进行评估及比较。结果：治疗组治疗后1周、2周和4周的总有效率显著高于对照组，治疗前2组患者的症状积分、餐前及餐后胃电参数指标、疾病相关血清指标及生活质量评分差异均无统计学意义（P 均＞0．05），而治疗后1周、2周和4周治疗组的症状积分低于对照组，餐前及餐后胃电参数指标及生活质量评分则高于对照组，血清一氧化氮（Nitric Oxide，NO）、白细胞介素1β（Interleukin-1β，IL-1β）及白细胞介素（Interleukin-6，IL-6）水平均低于对照组，血清5-羟色胺（5-hydroxytryptamine，5-HT）水平则均高于对照组，同时治疗组治疗后的上述评估方面也均好于本组治疗前的评估结果，差异均有统计学意义（P 均＜0．05）。结论：脾阴虚血瘀治疗方案在糖尿病性胃轻瘫患者中的综合应用价值较高，对于患者的症状改善及生活质量提升均有积极的临床意义。%Objective:To investigate the comprehensive value of spleen yin deficiency and blood stasis treatment in the patients with diabetic gastroparesis.Methods:A total of 120 patients with diabetic gastroparesis who were in accord with TCM spleen yin deficiency and blood stasis syndrome in our hospital from January 2014 to December 2015 were divided into two groups according to random number table,and the 60 patients in control group were treated with conventional western medicine treatment,the other 60 cases in observation group spleen yin deficiency and blood stasis treatment,the total effective rates at 1 st,2nd and 4th week after the treatment,symptom scores,gastric electrical parameters before and after meals,disease related serum indexes and life quality before the treatment and at 1 st,2nd and 4th week after the treatment were evaluated and compared.Results:The observation group′s total effective rates at 1 st,2nd and 4th week after the treatment were all significantly higher than the control group′s rates, all P <0.05,while the symptom scores,gastric electrical parameters before and after meals,disease related serum indexes and life quality scores before the treatment all had no obvious differences between the two groups,all P >0.05,while the observation group′s symptom scores at 1 st,2nd and 4th week after the treatment were all lower than control group′s scores,and the gastric electrical parameters before and after meal and life quality scores were all higher than control group′s scores.The serum nitric oxide(NO), interleukin-1β(IL-1β)and interleukin-6(IL-6)levels were all lower than those of control group,serum 5-hydroxytryptamine (5-HT)level was higher than the control group.And the those evaluation items of observation group were all better than those evalua-tion results before the treatment,all P <0.05.The differences were all significant.Conclusion:The spleen yin deficiency and blood stasis treatment has high comprehensive value in the patients with diabetic gastroparesis,and it also has positive significance in improving of symptoms and life quality of patients.