妇炎消胶囊联合西药治疗急性盆腔炎临床疗效及对患者血液流变学的影响

摘要

目的:探讨妇炎消胶囊联合西药治疗急性盆腔炎临床疗效及对患者血液流变学、炎性反应指标水平的影响.方法:选取2012年6月至2016年12月青海省交通医院确诊急性盆腔炎且中医证型属湿热内蕴型的患者89例,随机分为对照组和观察组,对照组45例采用左氧氟沙星及替硝唑静滴抗感染,观察组44例联合妇炎消胶囊口服,7d为1个疗程.比较治疗前后症状积分、血液流变学及超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-a)、白介素-2(IL-2)等指标改善情况,比较2组临床疗效及生命质量情况.结果:治疗后,患者下腹痛、带下增多、经量多等症状积分降低,差异有统计学意义(P＜0.05);患者血液流变学(低切血黏度、高切血黏度、血浆黏度)及炎性反应指标(TNF-a、hs-CRP)水平降低,IL-2则较前升高,但观察组均改善更显著(P＜0.05);治疗后,患者生命质量量表中躯体功能、情绪功能、心理功能、社会功能等维度均升高,但观察组水平更高(P＜0.05);对照组总有效率75.56％ (34/45),观察组为93.18％ (41/44),明显高于对照组(P＜0.05).结论:妇炎消胶囊联合西药治疗急性盆腔炎疗效显著,可更好地改善临床症状,抑制炎性反应渗出,纠正血液高凝状态,优于单用西医抗感染干预,值得推广.%Objective:To investigate the clinical curative effects of Fuyanxiao capsule combined with western medicine in treating acute pelvic inflammatory and effects on hemorheology and inflammatory indexes.Methods:A total of 89 cases with acute pelvic inflammatory disease of dampness heat syndrome,who were diagnosed in Qinghai Jiaotong Hospital from June 2012 to December 2016,were randomly divided into control group (45 cases) and observation group (50 cases).The control group was treated with levofloxacin and Tinidazole intravenous against infection,and the observation group was treated combined with Fuyanxiao capsules orally,with 7 d as a treatment course.The symptom scores,hemorheology,high sensitivity C reactive protein (hs-CRP),tumor necrosis factor (TNF-a) and interleukin-2 (IL-2) and other indicators before and after treatment were compared.The clinical efficacy and quality of life of both groups were compared.Results:After treatment,symptom scores of abdominal pain,increased leucorrhea,menorrhagia were reduced with significant difference (P ＜ 0.05);Patient's hemorheology (low blood viscosity,high blood viscosity,plasma viscosity) and inflammatory indicators (TNF-a,hs-CRP) were reduced,while the level of IL-2 was higher than before.But the observation group were improved more significantly (P ＜ 0.05);after treatment,in patient's quality of life scale,the dimensions of physical function,emotional function,psychological function,social function were increased,but the observation group was higher (P ＜ 0.05);the total efficiency of control group was 75.56％ (34/45),and the observation group was 93.18％ (41/44),which was significantly higher than the control group (P ＜ 0.05).Conclusion:Fuyanxiao capsules combined with western medicine treatment of acute pelvic inflammatory disease can significantly improve the clinical symptoms,inhibit the inflammatory exudate,correct the hypercoagulable state,which is better than single western medicine anti infection intervention,and is worthy of promotion.