滋阴调经颗粒治疗肝肾阴虚型围绝经期功能性子宫出血的临床疗效

摘要

目的:分析滋阴调经颗粒治疗肝肾阴虚型围绝经期功能性子宫出血的临床疗效.方法:本研究对象是2014年2月至2016年2月期间收治的80例肝肾阴虚型围绝经期功能性子宫出血患者.所有患者均采用动态随机化分法,分为观察组和对照组,各40例.对照组患者使用宫血宁胶囊进行治疗,观察组患者给予滋阴调经颗粒治疗,观察比较2组肝肾阴虚型围绝经期功能性子宫出血患者的临床疗效、治疗前后血清性激素指标、凝血功能.结果:观察组患者的总有效率达到了92.50％,高于对照组的72.50％ (P ＜0.05);观察组治疗前血清性激素指标与对照组治疗前比较,差异无统计学意义(P＞0.05),观察组患者治疗后FSH(11.29±3.62)mIU/mL、LH(12.30±3.46)mIU/mL、E2(85.73±5.82) pg/mL等指标均优于对照组(P＜0.05);观察组治疗前凝血功能与对照组相比较,差异无统计学意义(P＞0.05),观察组患者治疗后PT(10.20±1.38)s、APTT (23.10±3.51)s与对照组比较,优势更明显(P＜0.05).结论:采用滋阴调经颗粒对肝肾阴虚型围绝经期功能性子宫出血患者进行治疗的效果显著,能有效改善患者血清性激素指标及凝血功能.%Objective:To analyze the clinical curative effect of Ziyintiaojing Granules in the treatment of climacteric dysfunctional uterine bleeding of liver and kidney yin deficiency type.Methods:The objects of this study are 80 cases of climacteric dysfunctional uterine bleeding of liver and kidney yin deficiency type who were in our hospital from February 2014 to February 2016,dividing into a study group and a control group,each of 40 cases.Patients of the control group were given Gongxuening capsules and those of the other group were given Ziyintiaojing Granules.The clinical efficacy,serum sex hormone index and coagulation function before and after treatment were observed.Results:The total effective rate of the study group was 92.50％,higher than that of the control group,72.5 ％ (P ＜ 0.05);the difference of serum sex hormone index between the two groups before treatment was small (P ＞0.05);after treatment,FSH (11.29 ±3.62) mIu/mL,LH(12.30 ±3.46) mIu/mL,E2 (85.73 ±5.82) pg/mL and other indicators of the study group were better than those of the control group (P ＜ 0.05);as to coagulation,the two groups did not show much difference be treatment (P ＞ 0,05);after treatment,PT(10.20 ± 1.38) s and APTT(23.10 ± 3.51) s of the study group had more advantages compared with the control group(P ＜ 0.05).Conclusion:Ziyintiaojing Granules have significant effect in the treatment of climacteric dysfunctional uterine bleeding of liver and kidney yin deficiency type,which improves serum sex hormone and blood coagulation indexes and could be applied clinically.