小儿肠胃康颗粒治疗小儿腹泻疗效及安全性的Meta分析

摘要

目的:采用Meta分析的方法评价小儿肠胃康颗粒治疗小儿腹泻的疗效及安全性.方法:计算机检索PubMed、EMbase、The Cochrane Library(2015年第6期)、CBM、中国知网、维普数据库和万方数据库,搜集小儿肠胃康颗粒治疗小儿腹泻的相关随机对照试验或半随机对照试验,检索时限均为从建库至2015年6月.由2位研究者独立按纳入排除标准进行文献筛选、资料提取和方法学质量评价,然后采用RevMan 5.3软件进行Meta分析.结果:最终纳入13个研究共计1 395例患者.Meta分析结果显示在对照组的基础上联用小儿肠胃康颗粒治疗小儿腹泻的总有效率显著高于对照组4.2倍[RR=4.20,95％ CI(2.93-6.03),P＜0.05].按腹泻类型的亚组分析结果显示:小儿肠胃康颗粒治疗秋季腹泻的总有效率显著高于对照组4.3倍[RR =4.30,95％ CI(2.24-8.27),P＜0.05],小儿肠胃康颗粒治疗消化不良性腹泻的总有效率也显著高于对照组3.92倍[RR =3.92,95％CI(2.51-6.11),P＜0.05].结论:当前证据表明与单用其他药物比较,联合应用小儿肠胃康颗粒能显著改善小儿腹泻,特别是秋季腹泻和消化不良性腹泻.但受纳入研究质量和样本量的限制,当前的结果建议开展更多高质量和大样本的研究加以验证.%Objective:To evaluate the efficacy and safety of Xiaoer Changweikang Keli in the treatment of diarrhea in children using a meta-analytic method.Methods:We searched PubMed,Embase,The Cochrane Library (Issue 6,2015),CBM,CNKI,VIP and WanFang Databases from their inception to June,2015,to collect randomized controlled trials (RCTs) or quasi-RCTs of Xiaoerchan gweikangkeli for diarrhea in children.Two researchers independently screened literature according to the pre-specified inclusion and exclusion criteria,extracted data and evaluated the risk of bias of included studies.RevMan 5.3 software was used for all analysis.Results:A total of 13 studies including 1395 patients were included.The results of meta-analysis showed that,compared with control group,combined medication of the Xiaoerchangweikangkeli had significant improvement in overall efficacy rate 4.20 times (RR =4.20,95％ CI 2.93 to 6.03,P ＜ 0.05).Subgroup analysis according to type of diarrhea,compared with the control group,the Xiaoerchangweikangkeli had significant improvetment in efficacy for autumn diarrhea 4.30 times (RR =4.30,95％ CI 2.24 to 8.27,P ＜ 0.05) and lienteric diarrhea 3.92 times (RR =3.92,95％ CI 2.51 to 6.11,P ＜ 0.05).Conclusion:Current evidence showed that compared with independent use of other drugs,combined medication of Xiaoerchangweikangkeli could improve the overall efficacy rate for diarrhea in children,especially for autumn diarrhea and lienteric diarrhea.However,due to limited quality and sample size of included studies,more high quality studies with large sample size are necessary to verify the results.