中药灌肠联合体外电场热疗对慢性盆腔炎患者炎性因子、免疫功能及血流变学的影响

摘要

目的:探讨中药灌肠联合体外电场热疗对慢性盆腔炎(ChroniCpelvi Cinflammatorydisease,CPID)患者炎性因子、免疫功能及血流变学的影响.方法:选取2014年1月至2016年12月应城市人民医院收治的CPID患者500例,随机分为观察组与对照组,每组250例.所有患者均给予常规治疗,对照组在此基础采用体外电场热疗,观察组采用妇炎康胶囊灌肠联合体外电场热疗,2组均连续治疗30 d.统计2组临床疗效;比较2组治疗前后炎性因子、免疫功能及血流变学水平变化.结果:治疗后观察组的总有效率为94.40％,显著高于对照组的81.60％(P<0.05);治疗后2组患者血清IL-2水平较治疗前显著升高,且观察组显著高于对照组(P<0.01);治疗后2组血清IL-6、CRP及TNF-α水平均较治疗前显著下降,且观察组显著低于对照组(P<0.01);治疗后2组CD4+细胞比例及CD4+/CD8+比值均较治疗前显著升高(P<0.01),且观察组显著高于对照组(P<0.05或P<0.01);治疗后2组高/低切全血黏度、血浆黏度、红细胞聚集指数及纤维蛋白原水平均显著下降,且观察组显著低于对照组(P<0.01).结论:中药灌肠联合体外电场热疗治疗CPID可有效降低患者血清炎性因子水平,调节其免疫功能恢复正常,并显著改善其血流变学,从而提升临床疗效.%Objective:To explore the effects of Chinese herbal medicine enema combined with external electric field thermotherapy in vitro on inflammatory factors , immune function and hemorrheology in patients with chronic pelvic inflammatory disease ( CPID) . Methods:A total of 500 cases of CPID patients treated in our hospital were randomly divided into observation group and control group, with 250 cases in each group .All patients were given conventional treatment , patients in control group were treated with external field thermotherapy , patients in observation group were treated with Chinese medicine enema combined with external field thermotherapy in vitro .All the patients were treated for 30 days continuously .The clinical effects of 2 groups were statistically ana-lyzed , and the inflammatory factors , immune function and hemorrheology of 2 groups were compared before and after the treatment . Results:The total effective rate of observation group after treatment was 94.40％, which was significantly higher than 81.60％of control group (P<0.05);the serum IL-2 levels in 2 groups after treatment increased significantly compared with that before treat-ment, and observation group was significantly higher than control group (P<0.01);the serum IL-6, CRP and TNF-αlevels of 2 groups after treatment significantly decreased compared with before treatment , and levels of observation group were significantly lower than those in control group (P<0.01); the CD4 +cell proportion and CD4 +/CD8+ratio of 2 groups after treatment in-creased significantly compared with before treatment (P<0.01), and the levels in the observation group were significantly higher than those in control group ( P<0.05 or P<0.01 );the high/low shear whole blood viscosity , plasma viscosity , erythrocyte ag-gregation index and the fibrinogen levels of 2 groups after treatment decreased significantly , and the levels of observation group were significantly lower than those in control group (P<0.01).Conclusion:Chinese herbal medicine enema combined with exter-nal field hyperthermia in the treatment of CPID can effectively reduce the level of serum inflammatory factors , regulate its immune function to normal , and significantly improve its hemorrheology , thereby enhancing the clinical efficacy .