SASP加中药保留灌肠治疗溃疡性结肠炎64例

摘要

目的:观察柳氮磺胺吡啶(SASP)加中药保留灌肠治疗溃疡性结肠炎的临床疗效.方法:将溃疡性结肠炎患者128例随机分为对照组和观察组各64例.对照组口服SASP肠溶片,观察组同时采用中药汤剂保留灌肠治疗,1次/d.20天为1个疗程,疗程间间隔1周,连续治疗3个疗程.对比2组临床疗效及治疗前后Southerland DAI评分、内镜Baron评分和血清肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平的变化情况.结果:Southerland DAI评分、内镜Baron评分、每日大便次数治疗前后2组组内及组间比较,差异有统计学意义(P＜0.05).总有效率对照组为78.1％,观察组为93.8％,2组比较差异有统计学意义(P＜0.05).血清TNF-α和IL-6水平治疗前后2组组内及组间比较差异有统计学意义(P＜0.05).结论:SASP加中药保留灌肠治疗溃疡性结肠炎疗效确切,并能减轻患者机体炎症反应程度.%Objective: To observe clinical effects of salazosulfapyridine (SASP) and herbal retention enema in treating ulcerative colitis (UC). Methods: All 128 UC patients were randomized into the control group and the observation group, 64 cases each group. The control group took SASP enteric-coated tablets, and the observation group accepted herbal retention enema simultaneously, once each day. All 20 days were one course, the interval was one week, both groups were treated for three courses consecutively. The levels of IL-6 and TNF-α, endoscopic Baron scores, Southerland DAI scores and clinical effects of both groups were compared before and after treating.Results: The differences had statistical meaning in the comparisons of Southerland DAI scores, endoscopic Baron scores and the times of motions within two groups before and after treating, and between both groups (P＜0.05).Total effective rate of the control group was 78.1％, lower than 93.8％ of the observation group, and the difference showed statistical meaning (P＜0.05). The difference showed statistical meaning in the comparisons of the levels of TNF-α and IL-6 within two groups before and after treating, and between both groups (P＜0.05). Conclusion: SASP and herbal retention enema could obtain definite effects in treating UC, and it could relieve inflammatory reaction of the patients.