补虚固本、祛痰化瘀法对阵发性房纤颤患者血浆C-反应蛋白影响的临床研究

摘要

Objective:To observe the effects of filling weakness and fasting ben,expelling phlegm and removing blood stasis on the clinical efficacy and C-reactive protein levels in plasma in patients with paroxysmal anial fibrillation,and to explore the action mechanism of filling weakness and fasting ben to paroxysmal atrial fibrillation.Method:61 cases of patients with paroxysmal atrial fibrillation were divided into two groups according to 1:1 randomly, one group were treated with amiodarone and another group were treated with traditional Chinese medicine according to the method of filling weakness and fasting ben,2 months was one course of treatment, the follow-up time was 3 months,then to compare the situation of maintaining sinus rhythm,the diameter of left atrial,the levels of C-reactive protein and the incidence of adverse reactions before and after treatment. Result:The two groups had no significant difference in maintaining sinus rhythm after treatment(P＞0.05).The two groups had no significant difference in left atrial diameter before and after treatment,compared with the control group,there was no significant difference after treatment(P＞0.05).The C-reactive protein in plasma of the two groups were significantly reduced before and after treatment,there was a significant difference(P＜0.05).Compared C-reactive protein in plasma of the two groups,difference was significant(P＜0.01).Compared with the control group,the treatment group was significantly lower than the control group in adverse events(P＜0.05).Conclusion:The method of filling weakness and fasting ben has significant clinical effect in treating paroxysmal atrial fibrillation,it can treat paroxysmal atrial fibrillation through affecting the levels of C-reactive protein in plasma.%目的:观察补虚固本、祛痰化瘀法对阵发性心房纤颤患者临床疗效及血浆C-反应蛋白水平的影响,探讨其作用机制.方法:将阵发性心房纤颤患者61例按1∶1比例随机分为治疗组、对照组.对照组采用胺碘酮治疗,治疗组采用补虚固本、祛痰化瘀之复方中药治疗,2组均以2个月为1个疗程,随访时间为3个月,比较治疗前后窦性心律维持情况、左心房内径、C-反应蛋白的水平及不良反应发生率.结果:2组患者治疗后窦性心律维持情况比较无显著性差异(P＞0.05).治疗前后2组左房内径无显著性差异,治疗后与对照组比较无显著性差异(P＞0.05).治疗前后比较,2组血浆C-反应蛋白含量明显减少,有显著性差异(P＜0.05).治疗后2组血浆C-反应蛋白比较,亦有显著性差异(P＜0.01).治疗组不良反应明显低于对照组(P＜0.05).结论:补虚固本、祛痰化瘀法治疗阵发性心房纤颤患者临床疗效显著,其通过影响血浆C-反应蛋白水平而达到治疗目的.