三七总皂甙联合胺碘酮对阵发性房颤P波离散度和超敏 C-反应蛋白的影响

摘要

Objective To explore the effect of amiodarone alone or amiodarone in combination with Panax notoginsenosides(PNS) on P wave dispersion(Pd) and high sensitivity C-reactive protein(hs-CRP) in patients with paroxysmal atrial fibrillation (PAF).Methods Sixty PAF patients were randomly divided into study group (PNS combined with amiodarone) and control group(amiodarone alone),with 30 cases in each group.The follow-up lasted for 6 months.The recurrence of PAF was observed ,and the Pd and hs-CRP level were detected before and 6 months after treatment .Results Six months after treatment ,the Kaplan-Meier survival analysis suggested that the rate of sinus rhythm maintenance in the study group was significantly higher than that in the control group ( P<0.05) .The Pd and hs-CRP level in the study group were significantly lower than those in the control group after treatment (P<0.05).Conclusion Compared with amiodarone alone,Panax notoginsenosides combined with amiodarone can significantly reduce the recurrence of atrial fibrillation , decrease the Pd and hs-CPR level in PAF patients .%目的：探讨单用胺碘酮或联用三七总皂甙对阵发性房颤（ PAF ）患者P波离散度（ Pd ）和超敏C-反应蛋白（ hs-CRP）的影响。方法60例PAF患者随机分为研究组30例（三七总皂甙联用胺碘酮）与对照组30例（单用胺碘酮）。随访6个月，观察PAF复发情况，测定治疗前及治疗6个月后Pd及hs-CRP水平。结果在治疗6个月后，Kaplan-Meier分析显示研究组窦性心律维持率显著高于对照组（ P＜0．05）；治疗后研究组Pd、hs-CRP水平明显低于对照组（ P＜0．05）。结论三七总皂甙联用胺碘酮较单用胺碘酮可明显减少房颤复发，降低PAF患者Pd和hs-CRP水平。