胶原在止血材料中的应用

摘要

Collagen is a biomaterial with good and unique properties such as high tensile strength, biocompatibility and low cytotoxicity as well as capacity for promoting cell proliferation, and so on. As a hemostasis biomaterial, collagen is a hot research spot at home and abroad all the time. In this review collagen hemostasis materials were classified according to their physical shapes, and then the preparation technologies of several kinds of common collagen hemostatic materials and their evaluation for application in animal test and clinical test were analyzed. Finally, the future development trend of collagen hemostatic materials was prospected.%　　胶原具有如高拉伸强度、生物相容性和低细胞毒性以及促进细胞增殖分化等特点，是一种具有良好性能的生物材料，作为生物止血材料一直是国内外研究的热点。本文以胶原止血材料的物理形态分类，分析了几类常见形态的胶原止血材料的制备及在动物、临床试验的应用评价，并展望了未来胶原止血材料的发展趋势。