细胞周期素D1在口腔鳞状细胞癌组织中的表达及意义

摘要

Objective To investigate the expression and significance of Cyclin D1 in oral squamous cell carcinoma (OSCC).Methods A immunohistochemistry method, Envosion, was employed to test the manifesting levels of Cyclin D1 in pathological slices of 50 OSCC cases and 10 normal cases, and the results was treated with statistical analysis.Results In 50 OSCC cases, Cyclin D1 mainly manifested in karyon, and a little in cytoplasm.The positive manifesting rates of Cyclin D1 in the samples was 80.0％, which was significantly higher than the manifesting rates of 20.0％ in normal oral mucous membrane(P＜0.01).The manifestation of Cyclin D1 was correlated with the different pathological grades, clinical phases and lymph node metastasis (P＜0.05).Conclusion The abnormal manifestation of Cyclin D1 is closely related with the occurrence and development of OSCC.Therefore, it can be used as subsidiary index for OSCC treatment and prognosis.%目的 研究口腔鳞状细胞癌(OSCC)组织中细胞周期素D1(Cyclin D1)的表达及意义.方法 应用免疫组织化学Envosion法检测50例OSCC患者与10例正常黏膜组织中Cyelin D1蛋白在病理组织切片中的表达水平,并进行统计学分析.结果 在50例OSCC标本中Cyclin D1主要表达在细胞核,也有少量表达在细胞浆.Cyclin D1在OSCC标本中的阳性表达率80.0%,明显高于在正常口腔黏膜组织中的表达率20.0%,差异有统计学意义(P<0.01).Cyclin D1表达与OSCC病理分级、临床分期和是否有淋巴结转移密切相关(P<0.05).结论 Cyclin D1蛋白的异常表达与OSCC 的发生、发展有密切的关系,可作为OSCC治疗和预后的辅助性指标.