Objective To analyze the mechanism of fluorine by systemic analysis of fluorination-deminerarization-remineralization experiments. Methods The enamel specimens were randomly assigned to untreated group (group A), non-fluoride group (group B), low-fluoride group (group C) and high-fluoride group (group D). The in vitro model of fluoride enamel was established in group C and D. Based on that, the establishment of demineralization model and remineralization experiment by pH-cycling in group B, C and D were followed. All enamel specimens were observed by stereomicroscope and scanning electron microscope and compared in surface microhardness value. Results There was distinct difference in micro-morphologic appearance on fluoride enamel surface. Artificial caries of fluoride enamel showed a relatively complete surface, the surface microhardness after demineralization and remineralization in fluoride group was higher than non-fluoride group (P<0.05). Conclusion The fluorinated enamel can enhance cariostatic poten-tial and remineralization capacity of dental enamel.%目的 研究氟对脱矿和再矿化牙釉质表面的影响,探讨氟防龋的作用机理.方法 将牛牙釉质标本分为空白对照组(A组)、非氟化组(B组)、低氟化组(C组)和高氟化组(D组)4组,其中低氟化组和高氟化组依次进行氟化实验、脱矿实验和pH循环再矿化实验,非氟化组只进行脱矿实验和pH循环再矿化实验,空白对照组不做处理.在体视显微镜、显微硬度计和扫描电镜下观察各组釉质表面的形态变化,同时测量分析釉质表面显微硬度.结果 氟化牙釉质的表面微观形态显著不同,其脱矿损害具有相对完整的表层；氟化组在氟化、脱矿和再矿化后与非氟化组相比,表面显微硬度均有统计学差异(P＜0.05).结论 氟化牙釉质可增强牙釉质的抗龋能力和再矿化效能.
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