Helicobacter pylori (H. pylori) is one of the most common pathogens in human and it is closely related to gastrointestinal diseases. It is essential for us to understand the transmission process of H. pylori to prevent its spreading . The oral cavity has been proposed as a reservoir for gastric H. pylori, which has been detected by culture and polymerase chain reaction (PCR) in both dental plaque and saliva. Some researchers have proposed H. pylori in oral cavity may play an important role in its transmission and reinfection. Oral-oral or fecal-oral transmission are thought to be the most possible transmit way. This review will discuss the evidence for the role of the oral cavity in the transmission of H. pylori, the diffi-culties encountered in addressing this topic and possible directions for future research. Oral H. pylori may also play a role in the diagnosis and prevention of deceases related to H. pylori such as gastritis, gastric ulcer and gastric carcinoma. The recent progresses in this area are also reviewed. Moreover, we also discussed the relationship between oral H. pylori and oral deceases like periodontal disease and oral ulcer.%幽门螺杆菌是人类最常见的致病菌之一，它与胃部疾病密切相关。要防治幽门螺杆菌，了解其传播过程是必不可少的，而口腔幽门螺杆菌可能在幽门螺杆菌传播的过程中起到重要的作用。本文对近年来口腔幽门螺杆菌在幽门螺杆菌传播、诊断和预防方面所起的作用和目前研究所遇到的难点，以及口腔幽门螺杆菌与口腔疾病的关系等方面的研究新进展进行综述。
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