目的： 分析不同牙周健康状况者龈下菌斑中龈沟产线菌的检出率差异及其与牙周临床指标间的相关关系。方法 应用聚合酶链反应法分别检测17例牙周健康者的68个牙周健康位点、19例菌斑性牙龈炎患者的64个牙周健康位点和76个病变位点、14例慢性牙周炎患者的36个牙周健康位点和56个病变位点的龈下菌斑中龈沟产线菌的检出率，并分析检出率与牙周临床检查指标之间的相关关系。结果 龈沟产线菌的检出率在不同人群的健康位点组及不同人群疾病位点组依次分别增高，其中牙周健康者龈下菌斑中龈沟产线菌检出率最低，为30.88%（21/68），而慢性牙周炎患者病变位点组龈下菌斑中龈沟产线菌检出率最高，为91.07%（51/56）。龈沟产线菌与位点发生牙周病变之间的相关性有统计学意义（P<0.000 1），其检出率与位点牙龈出血指数、临床探诊深度、临床附着水平的比值比分别为5.26、8.85、11.65。结论 牙周炎患者口腔中携带龈沟产线菌的风险升高；局部携带龈沟产线菌增加了位点牙周临床指标（牙龈出血指数、临床探诊深度、临床附着水平）异常的风险。%Objective The study investigated the epidemiology of Filifactor alocis (F. alocis) in subgingival plaque samples from subjects with different periodontal statuses. The relationship between the prevalence of F. alocis and clinical periodontal parameters was also analyzed. Methods Subgingival plaque samples and periodontal data were collected from 68 healthy sites (H groups) in 17 healthy subjects, 64 healthy (G-H group) and 76 diseased sites (G-D group) in 19 patients with chronic gingivitis, and 36 healthy (P-H group) and 56 diseased sites (P-D group) in 14 patients with chronic periodontitis. The plaque samples were analyzed by polymerase chain reaction, and possible correlations between the F. alocis detection rate and the bleeding index, probing depth, or clinical attachment level were determined. Results The detection levels of F. alocis increased in both healthy and diseased groups. The lowest level at 30.88% (21/68) was noted in the H group, whereas the highest level at 91.07% (51/56) was obtained from the P-D group. A significant correlation was found between the F. alocis detection levels and periodontal disease condition (P<0.000 1). Further analyses showed that a significant correlation also existed between the detection level of F. alocis and the abnormal clinical periodontal parameters, namely, bleeding index, probing depth, and clinical attachment loss. The odds ratios were 5.26, 8.85, and 11.65, respectively. Conclusion F. alocis was found at increasedlevels in subjects with periodontal disease. The presence of F. alocis increases the risk of sites with abnormal clinical periodontal parameters.
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