目的： 观察口炎清颗粒对鼻咽癌患者放射性口腔炎的防治效果。方法 将60例鼻咽癌行适形调强放疗患者随机分为2组，口炎清组（30例）于放射治疗开始给予口炎清颗粒口服至放射治疗结束，对照组（30例）在放射治疗过程中出现2级及以上放射性口腔黏膜炎时，给予0.9%氯化钠注射液、利多卡因、地塞米松、维生素B12与维生素B2配制成漱口液含漱。采用全美放射肿瘤治疗协作组急性放射性黏膜炎的分级标准比较2组患者放射性口腔炎发生的时间、程度以及疼痛分级情况。结果 口炎清组和对照组放射性口腔炎出现的时间分别为（12.40±2.74）、（9.46±1.39） d，二者间差异有统计学意义（t=5.241，P<0.001）。口炎清组患者的疼痛分级、放射性口腔炎的分级比较均明显低于对照组，差异有统计学意义。结论 口炎清颗粒可延迟放射性口腔炎的发生时间，降低放射性口腔炎的严重程度，减轻患者疼痛，改善患者临床症状，有效防治鼻咽癌放疗引起的放射性口腔炎。%Objective The effect of Kou Yan Qing Ke Li on the prevention and treatment of radiation-induced oral mucositis was investigated in patients with nasopharyngeal carcinoma. Methods Sixty patients with nasopharyngeal carcinoma to be treated with radiotherapy were randomized into two groups: the experimental and control groups. The experimental group (30 patients) was treated with Kou Yan Qing Ke Li during the full course of radiotherapy. The control group (30 patients) rinsed their mouths in the same way with mouth washes containing 0.9% sodium chloride injection, lidocaine, dexamethasone, vitamin B12 and B2 gargle liquid mixture, when grade 2 and above radiation-induced oral mucositis appeared in the process of radiation. Radiation-induced oral mucositis was assessed according to the radiation therapy oncology group criteria. The time of occurrence and degree of pain grade were compared between the two groups. Results The first onset of oral mucositis in the experimental group (12.40 d±2.74 d) was later than that in the control group (9.46 d ± 1.39 d) (t=5.241, P<0.001), whereas the grade of pain and acute radiation mucositis was lower in the experimental group than that in the control group. The difference was statistically significant. Conclusion Kou Yan Qing Ke Li could delay the time of occurrence of radiation-induced oral mucositis, reduce the severity of radiation stomatitis, alleviate the pain of patients, improve the clinical symptoms of patients, and effectively prevent and treat radiation-induced oral mucositis in patients with nasopharyngeal carcinoma.
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