Association of alcohol consumption with colorectal cancer risk: a dose-response meta-analysis

摘要

Background:Currently,there are many meta-analyses on the correlation between alcohol conception and the risk of colorectal cancer,but the findings are inconsistent.We conducted a dose-response meta-analysis to investigate the association between alcohol intake and the risk of colorectal cancer.Methods:A literature search was performed on PubMed and EMBASE databases to identify relevant articles published before December 09,2019.Summarized relative risks(RRs)and 95%confidence intervals(CIs)were calculated using a fixed or random-effects model for the dose-response meta-analysis.The Cochran Q and I2 statistics were used to assess statistical heterogeneity among studies.Results:Five cohort and 19 case-control studies were included in the meta-analysis.An increased intake of 15-39.9g of daily alcohol was related to a 21%growth risk of CRC(RR=1.21,95%CI:1.05-1.38).Our dose-response analysis indicated that for drinkers of light,moderate and heavy level of alcohol drinking,the estimated RRs of CRC were 0.94(95%CI:0.69-1.27),1.08(95%CI:0.93-1.26)and 1.90(95%CI:1.29-2.97)respectively and for drinkers of moderate beer,heavy beer,moderate wine and heavy wine intake,the estimated RRs of CRC were 0.98(95%CI:0.72-1.34),1.48(95%CI:1.05-2.07),0.86(95%CI:0.56-1.34)and 1.04(95%CI:0.83-1.29)respectively.The risks with no significant association were consistent in the subgroup analyses of general alcohol consumption status and frequency.Conclusions:Heavy level of alcohol consumption,especially heavy beer intake seems to be associated with an increased the risk of CRC.