目的：利用Wistar大鼠实验探讨补充L-Arg对机体免疫功能的影响。方法：观察补充L-Arg对体液免疫、细胞免疫功能，血、尿NOx-水平以及脾脏形态学的影响，以及L-Arg对免疫抑制状态的调节作用。结果：一定剂量的L-Arg能够增强B细胞介导的体液免疫功能；对于体外培养的具有亲代B细胞活性的小鼠杂交瘤细胞株分泌功能无促进作用；不影响正常小鼠的T淋巴细胞转化功能；增强T细胞介导的Ⅳ型超敏反应；促进脾脏的免疫功能和淋巴小结增生；增加体内NO产生但不会造成NO及其代谢产物的蓄积。结论：补充一定剂量的L-Arg具有免疫增强作用。%Objective:To explore the influence of L-arginine supplement on immune function of rats and mice. Methods:To observethe change of humoral and cell immune response, the level of nitric oxide content in blood and urine, and the spleen morphology influenced by L-arginine supplement. Results:A certain dose of L-arginine could increase antibody production by B-cellmediated humoral immune response, intensify delayed hypersensitivity, and promote immune function of spleen and hyperplasia of lymph nodule. It didn＇t influence T-lymphocyte transform function in normal mice. There was no promoting function in the secretion of hybridoma in vitro with certain dose. L-arginine can increase the production of nitric oxide withoutstorage in the body. Conclusion: L-arginine supplement can enhance the body immune function.
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