子宫内膜异位症患者血清与腹腔液中RANTES水平及其临床意义

摘要

Objective To investigate the role and clinical significance of RANTES in endometriosis (EM). Methods The serum level of RANTES was examined by ELISA in 50 patients with endometriosis (EM group), 32 patients with benign ovarian neoplasms (disease control group) and 30 normal control women (normal control group). The level of RANTES in peritoneal fluid was examined in EM group and disease control group. Results The serum level of RANTES was significantly higher in EM group (108.73±60.69) ng/L than that of disease control group (31.26±20.33) ng/L and normal control group (29.77 ± 11.58) ng/L (P<0.05). The level of RANTES in peritoneal fluid was significantly higher in EM group (726.31 ± 259.83) ng/L than that of disease control group (116.19 ± 81.64) ng/L (P<0.05). The levels of RANTES in serum and peritoneal fluid in EM group were positively correlated with clinical stage respectively (rs=0.501 and 0.562,P<0.01). The level of RANTES in peritoneal fluid in EM group was positively correlated with dysmenorrhea score (rs=0.527,P<0.01). The serum level of RANTES was positively correlated with the level of RANTES in peritoneal fluid in EM group (rs=0.363, P<0.05). The levels of RANTES in serum and peritoneal fluid were positively correlated with inflammatory response degree in endometriotic tissues in EM group (rs=0.326 and 0.391,P<0.05 or P<0.01).Conclusion Detection of the serum level of RANTES by ELISA may be one of parameters for diagnosis of endometriosis.%目的探讨RANTES在子宫内膜异位症（EM）发生发展中的作用及临床意义。方法采用ELISA方法检测50例EM患者（EM组）、32例卵巢良性肿瘤患者（疾病对照组）以及30例正常妇女（正常对照组）血清中RANTES水平，检测EM组与疾病对照组患者腹腔液中RANTES水平，结合EM患者临床分期等资料进行比较分析。结果EM组患者血清中RANTES水平（108.73±60.69）ng/L明显高于疾病对照组（31.26±20.33）ng/L及正常对照组（29.77±11.58）ng/L（均P<0.05）。EM组腹腔液中RANTES水平（726.31±259.83）ng/L明显高于疾病对照组（116.19±81.64）ng/L （P<0.05）。EM患者血清以及腹腔液中RANTES水平与r-AFS分期均呈正相关(rs分别为0.501和0.562，均P<0.01)；腹腔液中RANTES水平与痛经评分呈正相关（rs=0.527，P<0.01）；血清中RANTES水平与腹腔液中RANTES水平呈正相关（rs=0.363，P=0.01）；血清及腹腔液中RANTES水平分别与病变组织炎症反应程度呈正相关（rs分别为0.326和0.391，P<0.05或P<0.01）。结论 RANTES在EM发生发展中起重要作用，ELISA方法检测EM患者血清中RAN-TES水平可以作为EM诊断的辅助指标。