目的：探讨C肽水平与2型糖尿病（T2DM）足部自主神经病变的关系。方法检测124例T2DM患者的空腹血糖（FBG）、餐后2 h血糖（2 h-PG）、空腹C肽（FC-P），利用欧米诺诊断膏贴测定足部神经泌汗功能，根据患者足部神经泌汗功能检查结果，分为糖尿病自主神经病变（DAN）组及非自主神经病变（NDAN）组，比较2组性别、年龄、体质指数、血压、FBG、2 h-PG、FC-P水平。将欧米诺诊断膏贴完全变色时间与上述指标进行Pearson相关分析。结果2组患者性别、年龄、FBG、2 h-PG比较差异无统计学意义（P＞0.05），DAN组患者FC-P水平为（1.07±0.75） nmol/L，低于NDAN组的（1.43±1.00）nmol/L（P＜0.05）。糖尿病足部欧米诺诊断膏贴变色时间与C肽呈负相关。结论 T2DM患者足部自主神经功能与C肽密切相关，推测C肽可能对足部自主神经具有保护性作用。%Objective To discuss the correlation between C-peptide level and autonomic neuropathy in diabetic foot in patients with type 2 diabetes mellitus (T2DM). Methods The levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h-PG) and fasting C-peptide (FC-P) were detected in 124 T2DM patients. The Neuropad was used to test functions of sudomotor nerves in foot. Patients were divided into two groups:diabetic autonomic neuropathy (DAN) group and non-autonomic neuropathy group (NDAN) according to the results of functions of sudomotor nerves in foot. Values of gender, age, body mass index (BMI), blood pressure, FBG, 2 h-PG and FC-P were compared between the two groups. The Pearson correlation analysis was carried out between the indexes mentioned above and the time for completing color change of Neuro-pad. Results There were no significant differences in gender, age, FBG and 2 h-PG between two groups (P>0.05). The FC-P level was (1.07 ± 0.75)nmol/L in DAN group, which was significantly lower than that in NDAN group (1.43 ± 1.00) nmol/L (P > 0.05). The time for completing color change of Neuropad was negatively correlated with C-peptide. Conclu-sion The autonomic nerve functions in diabetic foot is closely related with C-peptide. It is inferred that C-peptide may have protective effect on autonomic nerves in diabetic foot.
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