Many studies were published to evaluate the association between Nijmegen breakage syndrome 1(NBS1)657del5polymorphism and breast cancer risk,but the results remained inconsistent.To derive a more precise estimation on the possible association,we performed a meta-analysis of previous published studies.Case-control studies on the association between NBS1657del5 polymorphisms and breast cancer risk were included into this meta-analysis.We used the odds ratio(OR)with 95%confidence interval(95%CI)to assess the strength of the association.Ten studies with a total of 25,365 subjects were identified and included into this meta-analysis.Meta-analysis of those ten studies showed that there was a significant association between NBS1657del5 polymorphisms and breast cancer risk(pooled OR=2.66,95%CI 1.82-3.90,P<0.001).The cumulative meta-analyses showed a trend of a more significant association between NBS1 657del5 polymorphisms and breast cancer risk as data accumulated by publication year.Thus,our meta-analysis suggests that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk,and NBS1 657del5 polymorphism results in an increased risk of breast cancer.
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