新型立式网状宫内节育器对动物子宫肌电和内膜容受性的影响

摘要

This study is to explore the influence of new three-dimensional and reticular intra-uterine device (NTDR-IUD) on animal uterine electromyography and endometrial receptivity as the goal. Three types (short,median and long) of NTDR-IUD were placed into uterus of female white New Zealand rabbits. Conventional surgical incision was performed in the abdominal wall of rabbits,the uterine electromyography (EMG) was carried out by muscular electrophysi-ological testing. After placing NTDR-IUD,the slow wave frequency and average amplitude were increased. All of rabbits of control group were pregnant,and 5 pregnancies (fetal rabbits were found in the uterus without NTDR-IUD portion) in short group and 2 in median group. No pregnancy was found in the long NTDR-IUD group. The number of pregnant rabbits was signifi-cant difference between control group and the short ,median and long of NTDR-IUD group (P=0.000,P=0.033 and P=0.001). The contraceptive effect of NTDR-IUD may be by interfer-ing with uterine EMG,and related with its size and shape.%探讨新型立式网状宫内节育器（new three-dimensional and reticular intrauterine device，NTDR-IUD）对正常子宫肌电和内膜容受性的影响。制作3种规格（短、中及长）的IUD，放置在成年雌性新西兰大白兔子宫内，按常规无菌手术在耻骨联合正中切口切开腹壁，应用电生理仪进行子宫肌电检测。放置NTDR-IUD后，慢波频率加快，平均振幅增大，单波最大振幅增大，频率加快；短、中及长NTDR-IUD使兔子宫肌电爆发波的持续时间逐渐延长，最大振幅增大；10只正常对照组合笼1月后均妊娠，短NTDR-IUD组有5只在未被IUD占据的部位发现兔胎，中NTDR-IUD组有2只发现兔胎，长NTDR-IUD组未发现兔胎。妊娠只数长NTDR-IUD组与对照组比较，差异有统计学意义（P=0.000）；短NTDR-IUD组与对照组及长NTDR-IUD组比较，均有统计学意义（P=0.033），中等长度NTDR-IUD组与对照组比较，有统计学意义（P=0.001）。NTDR-IUD通过干扰子宫肌电参与避孕，其避孕效果与IUD大小有关。