广东地区痛风急性发作患者临床特点及用不同剂量秋水仙碱治疗差异

摘要

OBJECTIVE To investigate the clinical characteristics of gout patients in Guangdong province ,and the use of different doses of colchicine treatment difference .METHODS Select 150 cases of patients with acute gout attack for the study in April 2014 ~May 2015 admitted to various hospitals in Guangdong province .Clinical manifestations,causes and complications were analyzed , and the patients were randomly divided into three groups (A:0.5mg, B:1.0mg, C:1.5mg dose ), compare the therapeutic efficacy and incidence of adverse reac-・ 92・tions.RESULTS The total effective rate in group A (62.00%) were lower than group B (90.00%) and group C ( 94.00%) ,and has statistical significance ( P0.05).Group A,Group B gastrointestinal discomfort ,liver dysfunction,abnormal blood adverse drug reactions incidence has no statistically significant (P>0.05);and adverse drug reactions in groups A ,B were higher than group C,and has statistical significance (P<0.05).CONCLUSION Acute attacks of gout patients in Guangdong mainly for joints ,back pain ,laboratory tests for the C-reactive protein and serum uric acid levels rise ,the incentive for the drinking,the use of seafood.Using 1.0mg dose colchicine get the best treatment.%目的：探讨广东地区痛风急性发作患者临床特点，并使用不同剂量秋水仙碱治疗效果差异。方法选取2014年4月～2015年5月广东地区各医院收治痛风急性发作患者150例为研究对象，分析患者临床表现、诱因、并发症，并将患者随机分为3组分别采用0．5m、1．0mg、1．5mg剂量治疗，比较治疗效果和不良反应发生率。结果 A组患者治疗总有效率（62．00％）低于 B 组（90．00％）、C 组（94．00％），比较有统计学意义（ P＜0．05）；B、C两组治疗总有效率比较无统计学意义（ P＞0．05）。 A组、B组胃肠不适、肝功能损伤、血常规异常等药物不良反应发生率比较无统计学意义（P＞0．05）；且A、B两组患者药物不良反应发生率均高于C组，比较有统计学意义（P＜0．05）。结论广东地区痛风急性发作患者主要表现为关节、腰背痛，实验室检查为C反应蛋白和血尿酸水平升高，诱因为饮酒、食用海鲜等。采用1．0mg剂量秋水仙碱治疗可获得最佳治疗效果。