Objective The purpose of the clinic test is to study whether helicobacter pylori ( Hp ) colonizes transient and occasionally or is resident in dental plaque of oral cavity and to explore the relationship between the Hp in oral cavity and gastric infection. Methods Some 48 consecutive patients attending for routine diagnostic endoscopy for dyspepsia were recruited. Before endoscopy, samples of infragingival plaque were collected from two molar teeth. During gastroscopy, two biopsies were taken to the gastric antrum. Subsequently, the samples of dental plaque and gastric antrum were subjected to both the polymerase chain reaction ( PCR ) and the rapid urease test ( RUT ) respectively. Then the patients were divided into two groups on the basis of gastric Hp infection: group A made up of 28 HP-positive patients and group B of 20 Hp-negative patients. Six months later, these patients were informed to have a check again.Then we used the same methods to detect the Hp in the samples of dental plaque collected from patients. Results The rates of Hp infection in dental plaque were very low in both groups for both the two times. Although there was no significant difference between group A and group B, the difference between case six months ago and case later was obvious. Conclusions Hp may colonize in dental plaque by accident, and the dental plaque is not a potential reservoir and sanctuary for Hp.%目的 研究幽门螺杆菌(Hp)在牙菌斑中的偶居与定居的确定性,探讨牙菌斑中Hp与胃内Hp感染之间的关系.方法 随机选择行胃镜检查并主诉有上消化道症状的48例患者为研究对象,取其胃窦部活检标本2份和上下颌2个磨牙的龈下牙菌斑标本两份,内科治疗半年后再取同一患者上下颌两个磨牙龈下菌斑标本2份,分别行多聚酶链反应和快速尿素酶检测,以检测Hp的存在,然后对所得的数据实施统计学分析.结果 提示无论是6个月前还是6个月后,无论是胃内Hp阳性组还是胃内Hp阴性组的患者,其牙菌斑中Hp的检出率均很低.胃内Hp阳性组和胃内Hp阴性组的患者相比,2组差别无统计意义.但6个月后与6个月前相比,患者牙菌斑中Hp的检出率明显降低,差异有统计意义.结论 Hp口腔中提示是偶居,牙菌斑是Hp的储存库及是Hp躲避全身攻击的藏匿处的观点在本研究中没有得到证实.
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