血清SCC-Ag的变化对口腔鳞状细胞癌患者预后的影响

摘要

目的：研究血清鳞状细胞癌抗原（SCC -Ag）水平的变化对口腔鳞癌患者预后的影响。方法采用ELISA检测了58例口腔鳞状细胞癌（鳞癌）患者手术前后血清 SCC -Ag水平的改变。结果术前及术后血清 SCC -Ag 值＜1．5μg／L 的口腔鳞癌患者术后发生复发或转移发生率为15．6％和3．1％；术前和术后血清 SCC -Ag水平＞1．5μg／L 的口腔鳞癌患者术后发生复发或转移发生率为83．3％和95．5％；术前血清SCC -Ag水平＞1．5μg／L的口腔鳞癌患者术后血清SCC -Ag水平下降且SCC -Ag值＜1．5μg／L，其术后复发或转移发生率为25％。结论血清 SCC -Ag可能与口腔鳞癌的发生发展有关，其结果可作为判断患者病情的进展及肿瘤是否复发或转移。%Objective To investigate the effects of changes of serum squamous cell carcinoma antigen(SCC-Ag)levels on prognosis of oral cavity squamous cell carcinoma.Methods The changes of serum SCC-Ag levels in oral cavity squamous cell carcinoma patients before and after operation were detected by ELISA.Results The incidences of recurrence or metastasis in patients whose serum SCC-Ag value <1 .5 μg/L before and after operation were 1 5.6% and 3.1%;the incidences of recurrence or metastasis in patients whose serum SCC-Ag value >1 .5 μg /L before and after operation were 83.3 percent and 95.5 percent;as for the patients whose preopera-tive serum SCC-Ag level >1 .5 μg /L,their serum SCC-Ag levels fell and the postoperative SCC-Ag value <1 .5 μg /L,and the re-currence or metastasis rate was 25%.Conclusions Serum SCC-Ag may be related to the development of oral squamous cell carcino-ma,and the results can be used to evaluate the progress of the patient's conditions and the recurrence or metastasis of the tumor.