Objective:The aim of this study was to evaluate the clinical efficacy and side effects of docetaxel/cisplatin regiment and gemcitabine/cisplatin regiment in the patients with advanced non-small-cell lung cancer (NSCLC).Methods:Seventy-six patients with advanced NSCLC who were chemotherapy-naive were enrolled in two groups.In docetaxel group (DP group) the patients received docetaxel 75 mg/m 2 and cisplatin 60mg/m 2 on day 1.In gemcitabine group (GP group) the patients received gemcitabine 1000mg/m 2 on day 1 and day 8.The dosage of cisplatin was the same as DP group.The two regiments were administrated intravenously every 21 days as a cycle,each patient received 2-4 cycles.All patients were followed up until disease progressed or patients died.Results:The overall response rates were 43.5% in DP group and 45.9% in GP group.The response rate was significantly different between the initial treated group and retreated group in both two groups (53.8% vs 23.0% in DP group and 56% vs 25% in GP group,P<0.05,respectively).The main side effects were bone marrow suppression and thrombocytopenia.Conclusion:Docetaxel/cisplatin regiment and gemcitabine/cisplatin regiment for the patients with advanced NSCLC were efficient and well-tolerated chemotherapeutic approachs with low toxicity levels.The efficacy and major toxicity in two groups were similar.
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