Objective: The aim of this study was to investigate the efficacy of weekly docetaxel (TXT), cisplatin (DDP) combined with continuous infusion of low dose fluorouracil (FU) on advanced gastric carcinoma. Methods: Forty patients with advanced gastric carcinoma were randomly divided into two groups: the research group and the control group with 20 cases in each group. Patients in the research group were given TXT 40 mg/m2 on d1 and d8 plus DDP 30 mg/m2 on days 1, 3. FU 200 mg/m2 was infused continually from day 1-14. Patients in control group received ELF regimen therapy. Etoposide (VP-16) 120 mg/m2, calcium folinate (CF) 200 mg/m2, and FU 500 mg/m2 were given on days 1 and 3. Twenty-eight days were regarded as one cycle. At least two cycles must be completed. The short-term efficacy, adverse reaction, quality of life (QOL), and overall survival (OS) were recorded. Results: The clinical efficacy could be evaluated in 19 patients of research group and 17 patients in control group. The efficacy of research group was significantly better than that in control group (52.63% vs 17.65%, χ2 = 4.760, P = 0.041). However, the difference was not significant in the frequency of adverse reaction, QOL, median survival time, and OS between the two groups (P > 0.05). Conclusion: The short-term efficacy of weekly docetaxel and cisplatin plus low dose FU was better than traditional ELF regimen in the treatment of advanced gastric cancer. It had some value for clinical application.
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