Objective To study the characteristics of brian potential evoked by different emotion faces during sustained attention tasks in patients with internet addiction disorder(IAD)between before and after the treatment,and to analyze the correlation with treatment effect. Methods 38 patients met with the clinical diagnostic criteria for Internet addiction formulated(IAD group)before and after treatment and 38 healthy volunteers matched with sex,age and education(control group)were asked to fulfill the assignment after they were presented with 4 faces of joy,anger,sadness,fear and relative portal would been recorded. Then the N170 potentials evoked by emotion faces and P300 potentials evoked by target stimulus of the subjects were observed in the control group and IAD group before and after treatment. The Chinese Internet Addiction Scale(CIAS),Family Assessment Device(FAD),HAMD,HAMA were used to determine the internet addiction severity of tow groups and the curative efficacy of IAD group. To compare the characteristics of event related potentials between before and after treatment in IAD group,and compared with the control group,and the correlation a-nalysis were performed between them and the treatment effect(scale). Results ①The specific N170 wave amplitudes in the temporal occipital stimulated by emotion faces were smaller in patients with IAD before treatment than in the controls[e. g. fear faces,(17. 5 ± 16. 7)μv vs. (25. 8 ± 13. 4)μv,P < 0. 05]. The P300 latencies in parietal occipital stimulated by emotion faces were longer in patients with IAD before treatment than in the controls[e. g. fear faces,( 452. 6 ± 50. 3)ms vs.(426. 7 ± 28. 4)ms,P < 0. 05]. There were no significant difference in evoked N170 amplitude and latency among different emotion faces,and the smallest P300 ampli-tude and the longest P300 latency were found in patients with IAD before treatment during the sustained attention tast to the fear faces.②There were no significant difference in evoked amplitudes and latencies of N170 or P300 stimulated by 4 emotion faces in IAD group after treatment than in the controls,respectively(all P > 0. 05). ③The negative correlation was found between the evoked N170 ampli-tudes stimulated by 4 emotion faces and the scores of scales(CIAS,FAD,HAMa + d),P300 latencies was positively correlated with the scores. No correlation was found between the evoked N170 latencies ,P300 amplitudes and the scores of scales. Conclusion It suggests that patients with IAD show less reactivity to the fear stimuli which might indicate that fear faces could affect IAD patientsˊemo-tional regulation and their sustained attention. There were positive correlation between N170 amplitudes and the efficacy,negative cor-relation between P300 latencies and the efficacy in patients with IAD.%目的：探讨不同情绪面孔刺激下网络成瘾（IAD）者执行持续注意任务时的事件相关电位特征，并分析其与治疗转归的相关性。方法选取符合网络成瘾临床诊断标准的38例网络成瘾者（研究组，IAD 组）及性别、年龄、受教育年限与之相匹配的38例健康志愿者（对照组），在喜（愉悦）、怒（愤怒）、悲（悲伤）、恐（恐惧）4种情绪面孔刺激随机呈现后执行注意与选择任务，同时记录事件相关电位，观察 IAD 组治疗干预前后及对照组在4种情绪面孔诱发的 N170电位及靶刺激诱发的 P300电位的特征。采用中文网络成瘾量表（ CIAS）、家庭功能评定量表（FAD）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）评定网络成瘾严重程度和 IAD 组治疗效果。比较 IAD 组治疗干预前后及与对照组间的事件相关电位的差异与特征，分析其与治疗效果（量表）的相关性。结果①IAD 组治疗前在4种情绪面孔刺激下颞枕区 N170波幅均低于对照组[如恐惧面孔，（17.5±16.7）μv vs.（25.8±13.4）μv，P ＜0.05]，顶枕区 P300潜伏期均长于对照组[如恐惧面孔，（452.6±50.3）ms vs.（426.7±28.4） ms，P ＜0.05]。IAD 组在4种情绪面孔刺激下诱发的 N170波幅和潜伏期差异均无统计学意义（P 均＞0.05）；诱发的 P300 在4种情绪面孔刺激中以恐惧面孔刺激后执行注意任务的 P300波幅最低，潜伏期最长。②IAD 组干预后在4种情绪面孔刺激下诱发的 N170和 P300波幅和潜伏期与对照组比较差异均无统计学意义（P 均＞0.05）。③在4种情绪面孔刺激下诱发的 N170波幅与量表评分呈负相关，P300潜伏期与量表评分呈正相关；N170潜伏期、P300波幅与量表评分无显著相关性。结论网络成瘾者在4种情绪面孔刺激下以恐惧面孔刺激诱发的 P300波幅最低、P300潜伏期最长；经治疗好转，N170波幅及 P300潜伏期恢复到正常水平，N170波幅与疗效呈正相关，P300潜伏期与疗效呈负相关。
展开▼
