To discuss the changes of coagulation and anticoagulation system on older people with severe pancreatitis. Methods To select the patients of MAP, SAP, health into three groups and each with 40 cases. All the patients were extracted the morning fasting blood 2ml for coagulation testing. Then comparing the PT, APTT, FIB and D-dimer. Results The value of PT, APTT, FIB and D-dimer in SAP group were significantly higher than MAP and health group, and the index in MAP were significantly higher than health group (P < 0.05 ). Conclusion The coagulation and anticoagulation system of older patients with severe pancreatitis has abnormality and affect normal microcirculation, PT, APTT, FIB and D-dimer can be used as indicators to understand the progression of the disease in patients with SAP. And it has clinical significance for preventing of SAP complications.%目的 探讨老年重型胰腺炎(SAP)患者机体凝血和抗凝系统的变化情况.方法 轻型胰腺炎(MAP)、SAP、健康者各40例编入三组,均于入组后首个清晨取空腹血液2ml进行凝血功能检测,比较凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)和D-二聚体的变化情况.结果 SAP组患者PT、APTT、FIB和D-二聚体值均明显高于健康组和MAP组,MAP组患者凝血功能指标值明显高于健康组,P＜0.05.结论 老年SAP患者机体内的凝血和抗凝系统存在明显的异常性,影响正常的微循环,PT、APTT、FIB和D-二聚体可作为检测指标了解SAP患者的病情发展,并对预防SAP并发症有一定的临床意义.
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