小剂量米非司酮联合妈富隆与米非司酮治疗功能失调性子宫出血的疗效比较

摘要

目的 探讨低荆量米非司酮联合妈富隆与米非司酮治疗功能失调性子宫出血的疗效分析.方法 选择我院自2009年1月~2011年1月收治的184例功能性子宫出血患者,将184例患者随机分为两组,对照组88例给用米非司酮,治疗组96倒给予低剂量米非司酮联合妈富隆.比较两者患者临床效果,患者血清促卵泡素(FSH)、黄体生成素(LH)、雌激素(E2)水平,不良反应.结果 治疗组总有效率为100.0%,对照组总有效率为95.3%,治疗组与对照组比较,显效率及总有效率均显著高于对照组,总体治疗比较,P<0.05.治疗后治疗组FSH水平显著低于对照组,P<0.05.而治疗后LH、E2水平差异无统计学意义,P>0.05.两组均未出现严重不良反应.结论 小剂量米非司酮与妈富隆联用治疗功能失调性子宫出血,相对于使用正常剂量米非司酮临床疗效佳,止血效果好,是安全的治疗方法,适合临床推广.%Objective To evaluate the therapy of dysfunctional uterine bleeding with low dose Mifepristone and Marvelon and Mifepristone. Methods We analyzed 184 cases who had dysfunctional uterine bleeding in our department from January 2009 to January 2011 , all cases were randomly divided into 2 groups of 96 cases in the control group who had given low dose Mifepristone and Marvelon, and 88 case in experimental group who had given low dose Mifepristone. Contrast the therapeutic effect and the level of FSH, LH, E2 and adverse effect. Results The total effective rate was 95. 3% and 100% in the two groups (P <0. 05) and the rate of excellence was higher in the control group. The level of LH, E2 were no significant differences pretherapy (P > 0. 05 ) , the level of FSH were significant differences ( P < 0. 05 ) post-treatment. There were no serious aderse effect. Conclusion Low dose Mifepristone and Marvelon had higher effect than Mifepristone in the dysfunctional uterine bleeding, and had good ef-fection of stanch bleeding, safey.