Objective To study the clinical effect of ibandronate(IB) plus simvastatin in treating osteoporosis in senile patients. Methods 110 elderly patients with osteoporosis were randomly divided into 2 groups, each group for 35 patients. 55 patients in control group were intravenous injected with IB alonely. 55 patients in treatment group took IB plus simvastatin. The course of treatment was 8 months. The bone mineral density( BMD) changes of left distal ulna, waist2-4( 12-4) , Wards triangle location, the improvement of clinical pain symptoms and biochemical indicators were recorded before and after treatment. Results BMD after treatment in three locations were increased significantly than those of before treatment in two groups ( P < 0.01). The BMD improvement in L2-4 and Wards triangle location in treatment group were more significantly than those of control group ( P < 0.05 ). The total effective rate of improvement of of clinical pain symptoms in treatment group was 92.3% , significantly higher than that of control group (81. 8% , P < 0.05 ). There were no significantly changes in biochemical indicators between before treatment and after treatment. Conclusion The combination of IB with statin drug simvastatin presents a synergy effect on osteoporosis in senile patients.%目的 观察伊班膦酸钠联合他汀类药物对老年性骨质疏松症患者的临床疗效.方法 将110例老年性骨质疏松症患者随机分为两组,每组55例,对照组单独静脉注射伊班膦酸钠,治疗组给予伊班磷酸钠和辛伐他汀,整个疗程共8个月.观察治疗前后左侧尺骨远端、腰2-4、Wards三角部位的骨密度变化,临床疼痛症状改善的疗效和生化指标的变化.结果 两组患者治疗后三个观察部位的骨密度较治疗前均有明显上升(P＜0.01)；治疗组腰2-4、Wards三角区的骨密度上升幅度明显大于对照组(P＜0.05).治疗组疼痛症状改善的总有效率为92.3％,明显高于对照组的81.8％(P＜0.05).两组治疗前后生化指标无明显变化.结论 他汀类药物辛伐他汀对伊班膦酸钠治疗老年性骨质疏松症具有协同作用.
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