2型糖尿病患者血浆致动脉硬化指数与踝肱指数的相关性

摘要

目的 探讨2型糖尿病患者血浆致动脉硬化指数(atherogenic index of plasma,AIP))与踝肱指数(ankle brachial index,ABI)的相关性.方法 纳入143例2型糖尿病患者,测定双下肢动脉血管压力和肱动脉血管压力,计算踝肱指数,测量身高、体重、血脂、肌酐、尿酸、HbA1c、超敏反应蛋白(sCRP)尿白蛋白/肌酐(ACR)、计算血浆致动脉硬化指数[log(TG/HDL-c)].依照踝肱指数分为两组:ABI ＜0.9和0.9≤ABI＜ 1.4组.结果 ①两组相比,AIP、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、sCRP、ACR差异均有统计学意义(P＜0.05).②单因素分析表明,ABI与AIP、TG、TC、HDL、LDL、SCRP、ACR相关(P＜0.05).其中ABI与AIP相关系数最大r=0.484.③以ABI为因变量,以其余各因素为自变量作多元回归分析,结果表明血浆致动脉硬化指数(P＜0.000)、ACR(P ＜0.000)、SCRP(P＜0.000)进入方程.结论 AIP与2型糖尿病患者ABI具有较好的相关性,可以作为2型糖尿病患者外周血管疾病的有用指标.%Objective To investigate the relationship of atherogenic index of plasma( AIP) to ankle brachial index( ABI) in patients with type 2 diabetes. Methods 143 subjects with type 2 diabetes were included, ankle brachial index, height, weight, blood lipid, acidum uricum.creatinine, HbAlc, urine albumin to crean'nine( ACR) were measured and AIP( log(TG/ HDL-c) ) was calculated. The subjects were divided into two groups according to ABI: ABI?0.9 and 0.9 < ABI < 1.4. Results ? There was significant difference in AIP, TG, HDL-c, LDL-c, sCRP, ACR(P <0.05) between the two groups. ?HDL-c was inversely related to ABI. AIP, TG.TC.LDL, SCRP, ACR were positively related to ABI(P <0.05). The orrelation coefficient of ABI and AIP was 0.484. ?Multivariate analysis by linear regression showed that AIP (P < 0. 000 ) , ACR ( P < 0.000 ) , sCRP ( P < 0. 000) were included. Conclusion In patients with type 2 diabetes, AIP is an important risk factor in pathogenesis and progress of peripheral arterial disease.