目的 探讨早期胰岛素强化治疗对初诊2型糖尿病患者的胰岛β细胞功能和长期血糖控制的影响.方法 选择158例新诊断的2型糖尿病患者,随机分成早期胰岛素治疗组(胰岛素组)和口服降糖药物治疗组(对照组),其中胰岛素组按疗程分为15d亚组、30d亚组.比较治疗前后FPG、2hPG、HbA1c、Fins、2hins、Fc-p、2hc-p、HOMA-IR和HOMA-β(c-p).结果 胰岛素组较对照组胰岛β细胞功能明显改善(P<0.05);其中30d亚组较15d亚组改善明显(P<0.05).结论 对血糖明显升高的初诊2型糖尿病患者,早期胰岛素强化治疗能明显改善胰岛β细胞功能并减轻胰岛素抵抗.%Objective To evaluate the effect of early intensive insulin therapy to β-cell function and glycemic control of patients with newly diagnosed type 2 diabetes. Methods 158 patients with newly diagnosed type 2 diabetes were randomly assigned to either intensive insulin therapy or standard oral hypoglycaemic agents (control) groups. Treatment of intensive insulin therapy group was followed-up to 15 days and 30 days. The changes of laboratory datas including p-cell function, FPG, 2hPG, HbAlc, Fins, 2hins, Fc-p, 2hc-p, HOMA-IR and HOMA-β ( c-p ) were measured before and after treatment. Results p-cell function of intensive insulin therapy group improved more significantly than that of control group ( P < 0. 05 ) , 30 days insulin therapy improved more significantly than that with 15 days ( P < 0. 05 ) . Conclusion Early intensive insulin therapy in patients with newly diagnosed type 2 diabetes can improve p-cell function and reduce insulin resistance.
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